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Sulfates are the key circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The primary oxidative metabolite is 2-hydroxy ethinyl estradiol, formed because of the CYP3A4 isoform of cytochrome P450. Component of the first-go metabolism of ethinyl estradiol is thought to manifest in gastrointestinal mucosa. Ethinyl estradi